Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle
نویسندگان
چکیده
منابع مشابه
MUSCARINIC RECEPTOR SUBTYPES IN SMOOTH MUSCLE FROM THE BODY OF HUMAN STOMACH
Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...
متن کاملIntracellular ATP slows time-dependent decline of muscarinic cation current in guinea pig ileal smooth muscle.
The effects of intracellular nucleotide triphosphates on time-dependent changes in muscarinic receptor cation currents (I(cat)) were investigated using the whole cell patch-clamp technique in guinea pig ileal muscle. In the absence of nucleotide phosphates in the patch pipette, I(cat) evoked every 10 min decayed progressively. This decay was slowed dose dependently by inclusion of millimolar co...
متن کاملATP release and contraction mediated by different P2-receptor subtypes in guinea-pig ileal smooth muscle.
1. The present study was addressed to clarify the subtypes of P2-purinoceptor involved in ATP release and contraction evoked by alpha, beta-methylene ATP (alpha, beta-mATP) and other P2-agonists in guinea-pig ileum. 2. alpha, beta-mATP 100 microM produced a transient and steep contraction followed by ATP release from tissue segments. These maximum responses appeared with different time-courses ...
متن کاملthe inhibitory effects of ferula assafoetida on muscarinic receptors of guinea-pig tracheal smooth muscle
conclusions these results showed an inhibitory effect for the extract of asafetida on muscarinic receptors of tracheal smooth muscle. results the ec50 obtained in the presence of higher concentration of the extract muscle was significantly higher compared to saline (p < 0.01). the maximum responses to methacholine in the presence of higher concentration of the extract (10 mg/ml) was significant...
متن کاملmuscarinic receptor subtypes in smooth muscle from the body of human stomach
up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (m1, m2, m3 and m4). in our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. isolated preparations of longitudinal and circular muscle layers from human stomach were used. acetylcholine, bethanechol, carbachol, pilocarpine and ahr -602 produced concentrati...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1997
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0701438